MINING METAGENOMES AND METATRANSCRIPTOMES UNVEILS VIRUSES ASSOCIATED WITH CUTANEOUS SQUAMOUS CELL CARCINOMA IN HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS

Mining metagenomes and metatranscriptomes unveils viruses associated with cutaneous squamous cell carcinoma in hematopoietic stem cell transplant recipients

ABSTRACT We investigated the presence of viral DNA and RNA in cutaneous squamous cell carcinoma (cSCC) tumor and normal tissues from nine individuals with a history of hematopoietic stem cell transplantation (HCT).Microbiome quantification through DNA and RNA sequencing (RNA-seq) revealed the presence of 18 viruses in both tumor and normal tissues.

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Fatty acid metabolization and insulin regulation prevent liver injury from lipid accumulation in Himalayan marmots

Summary: Fat storage and weight gain are dominant traits for hibernating mammals.However, excessive t jazelle bracelet fat accumulation may cause liver damage.Here, we explore the lipid accumulation and metabolic processes of the Himalayan marmot (Marmota himalayana), a hibernating rodent species.We find that the unsaturated fatty acid (UFA) conten

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Allometric trajectories and "stress": a quantitative approach

The term stress is an important but vague term in plant biology.We show situations in which thinking in terms of stress is profitably replaced by quantifying distance from functionally optimal scaling relationships between plant parts.These relationships include, opi mauvnetic poles for example, the often-cited one between leaf area and sapwood are

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